Wednesday, March 3, 2010

Seminar Opportunity: ACS Webinar (take notes for seminar credit)

MIDA Boronate Building Blocks:
Towards a general platform for small molecule synthesis

Live Webinar: March 23, 2010
2:00 p.m. EST • 1:00 p.m. CST • 12:00 p.m. GMT • 11:00 a.m. PST

Broadcast live at the ACS Spring National Meeting
Room 114N

Register Now

Overview: In an idealized form of the building block approach for small molecule synthesis, off-the-shelf subunits having all of the required functional groups preinstalled in the correct oxidation states and with the desired stereochemical relationships are brought together via the recursive application of one stereospecific reaction. Analogous to peptide coupling, this strategy aims to maximize the simplicity, efficiency, and flexibility with which small molecules can be made in the laboratory. MIDA boronates represent a powerful platform of building blocks with the potential to broadly enable this type of synthesis.

The webinar will discuss the many physical and chemical features of MIDA boronates that underlie their widespread utility, including:
  • Ease of preparation, purification, and storage and minimized environmental impact
  • Reversibly attenuated boronic acid reactivity that enables small molecule synthesis via iterative cross-coupling
  • Capacity for slow-release cross-coupling that transforms even notoriously unstable 2-heterocyclic, vinyl, and cyclopropyl subunits into air-stable and highly effective cross-coupling partners
  • Compatibility with a wide range of common reaction conditions which enables the multistep synthesis of structurally complex boronic acids from simple B-containing starting materials
Your host for this webinar will be:

Martin D. Burke, Ph.D., M.D.
Assistant Professor of Chemistry
Early Career Scientist of the
Howard Hughes Medical Institute
University of Illinois at Urbana-Champaign


A. Maureen Rouhi, Ph.D.
Deputy Editor-in-Chief

Who Should Attend?
  • synthetic organic chemists
  • medicinal chemists
  • process chemists
  • leaders in the pharmaceutical industry
  • instructors of organic chemistry courses

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