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Wednesday, March 3, 2010
Seminar Opportunity: ACS Webinar (take notes for seminar credit)
MIDA Boronate Building Blocks: Towards a general platform for small molecule synthesis
Live Webinar: March 23, 2010 2:00 p.m. EST • 1:00 p.m. CST • 12:00 p.m. GMT • 11:00 a.m. PST
Broadcast live at the ACS Spring National Meeting Room 114N
Overview: In an idealized form of the building block approach for small molecule synthesis, off-the-shelf subunits having all of the required functional groups preinstalled in the correct oxidation states and with the desired stereochemical relationships are brought together via the recursive application of one stereospecific reaction. Analogous to peptide coupling, this strategy aims to maximize the simplicity, efficiency, and flexibility with which small molecules can be made in the laboratory. MIDA boronates represent a powerful platform of building blocks with the potential to broadly enable this type of synthesis.
The webinar will discuss the many physical and chemical features of MIDA boronates that underlie their widespread utility, including:
Ease of preparation, purification, and storage and minimized environmental impact
Reversibly attenuated boronic acid reactivity that enables small molecule synthesis via iterative cross-coupling
Capacity for slow-release cross-coupling that transforms even notoriously unstable 2-heterocyclic, vinyl, and cyclopropyl subunits into air-stable and highly effective cross-coupling partners
Compatibility with a wide range of common reaction conditions which enables the multistep synthesis of structurally complex boronic acids from simple B-containing starting materials
Your host for this webinar will be: Martin D. Burke, Ph.D., M.D. Assistant Professor of Chemistry Early Career Scientist of the Howard Hughes Medical Institute University of Illinois at Urbana-Champaign