Natural Biomarkers for Monitoring Bioenergetics in Living Cells
Ahmed A. Heikal
Department of Chemistry and Biochemistry, Swenson College of Science and Engineering,
University of Minnesota-Duluth, MN, 55812, USA
Abstract: Reduced nicotinamide adenine dinucleotide (NADH) is a key cofactor in energy
metabolism pathways and a myriad of oxidation-reduction reactions in living cells. NADH is
naturally fluorescent and its emission is rather sensitive to protein binding. As a result, NADH
autofluorescence would allow for noninvasive and ultimately quantitative monitoring of energy
metabolism in living cells. In this seminar, I will highlight our efforts in establishing NADH as a
natural biomarker for cellular energy metabolism, mitochondrial anomalies and related health
problems. Macromolecular crowding effects on enzyme binding reactions with NADH will also
be discussed using a combination of both fluorescence microscopy and spectroscopy methods
Thursday, February 19, 2015
Students please visit the UNLV REU Site: Mechanisms of Evolution website.
Undergraduate projects funded by the REU Site: Mechanisms of Evolution focus on biological processes that drive heritable change. The inspiration for this proposal is the celebrated essay, Nothing in Biology Makes Sense Except in the Light of Evolution by Theodosius Dobzhansky. The goals of this proposal are to provide undergraduates with hypothesis-based projects that investigate one or more mechanisms of evolution, promote careers in science and reinforce the connection between genetics and evolution.
Students from underrepresented groups and those that attend academic institutions with limited research opportunities, including two-year colleges are strongly encouraged to apply.
The grant provides a travel subsidy, housing and stipend.
edu/microreu for the application, a list of mentors and additional details.
Wednesday, February 11, 2015
Over the years many of us have been asked or volunteered to talk with a variety of audiences about our work and our perspective as scientists on topics of the day. In the not so distant future, you will need these skills as well. The ability to tell a compelling, coherent, engaging story will serve you well. Recently, Ronald Hites, editor of the ACS journal Environmental Science and Technology, wrote a piece that presents some suggestions on how to give scientific talks and posters and on how to get started writing research papers and proposals. It is well worth the read and follow-up conversations with trusted mentors and friends. Enjoy exploring the paper; oral and written communication play critical roles in daily life as well as one's work life. For those having done summer research here at St. Olaf, many of the paper's take home messages should resonate!
I am writing to request your assistance in identifying outstanding undergraduates who might be interested in, and qualified for, the ACS sponsored Nuclear and Radiochemistry Summer School Program. We are seeking curious and highly motivated students with strong science backgrounds. If selected, these students receive an all-expense paid opportunity to complete a 6 week summer course in Nuclear and Radiochemistry in either California or New York. They also earn hours (tuition paid) of undergraduate chemistry credit through either San Jose State University or SUNY-Stony Brook. Selected students also receive a stipend of $4,000.
An announcement for the Nuclear and Radiochemistry Summer Schools that can be posted is attached to this request. It describes the application procedure and the background we hope applicants will have when applying. This information and an on-line application form can also be found on the web at:
The deadline for applications is. Please distribute this announcement to your undergraduate students and encourage them to consider this unique opportunity! If you or your students have any questions about the ACS sponsored program, please do not hesitate to contact me using the information below.
Thanks, in advance, for your assistance.
J. David Robertson, National Director
ACS Summer Schools in Nuclear and Radiochemistry
Department of Chemistry
University of Missouri
Columbia, MO 65211
Sunday, February 1, 2015
In 1951, a little known chemist working at Syntex in Mexico City, achieved the first chemical synthesis of an oral contraceptive steroid. Dr. Carl Djerassi went on to do a large variety of work aimed at benefiting the chemical sciences, forwarding graduate chemical education as a faculty member, and improving the relationship between science and society - especially the arts (literature and theatre). We now celebrate a life well-lived. For those interested, check out the links below or simply search the web, SciFinder Scholar, or Web of Knowledge for works and contributions by Djerassi.
TEDx Vienna (YouTube)
Oxygen (the play!)
TEDx Vienna (YouTube)
Oxygen (the play!)