Protecting Your Proteome: the Upside of Folding Under Stress
Monday December 3rd, RNS 410, 4:00
Kevin Strange
Zoology and Physiology
Mountain Desert Island
Biological Lab
Maintenance of the conformation, concentration, interactions, localization, and hence function of cytoplasmic proteins is termed protein homeostasis or “proteostasis”. Proteostasis is maintained by the tightly integrated and balanced activities of gene transcription, RNA metabolism and protein synthesis, folding, assembly, trafficking, disassembly and degradation. Because protein structure is inherently unstable and can be readily disrupted by gene mutations and cellular stresses, cells “live on the edge of a proteostasis catastrophe”. My laboratory uses the nematode worm C. elegans to understand how cells cope with environmental stress. This seminar will describe how one cellular stress, dehydration, damages proteins and how cells recover and protect themselves from this
damage.
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