Nanodiscs, Membrane Proteins, and Mass Spectrometry: New Tools for Studying Protein-Lipid Interaction
Dr. Michael Marty, '10
Friday September 26th, 3:15, Regents 310
Membrane proteins play a critical role in biochemistry, bioenergy, and pharmaceuticals. However,
little is known about interactions between membrane proteins and their lipid bilayer environment.
This is largely due to a lack of adequate tools for quantifying these complex interactions. Nanodiscs,
nanoscale lipoprotein particles modeled after HDL, provide a unique platform for studying
membrane proteins in a homogeneous and monodisperse lipid bilayer environment. I will present
research examining membrane proteins embedded in Nanodiscs with native ion mobility-mass
spectrometry. Native mass spectrometry preserves noncovalent interactions, allowing detection
of the intact membrane protein-Nanodisc complex as well as metastable dissociation products.
Comparing the masses of these dissociation products with molecular dynamics simulations
reveals a “magic number” of lipids that corresponds to the number of polar contacts between
the membrane protein and its lipid bilayer annular belt. This combination of nanotechnology,
biochemistry, and mass spectrometry provides new tools for quantifying interactions between the
lipid bilayer and membrane proteins.
Welcome to the Chemistry Department Blog. This is the place for Chemistry Majors to get department news and current events.
Friday, September 19, 2014
Tuesday, September 9, 2014
Canon River Clean-Up
The Canon River Watershed Partnership (CRWP) is asking for volunteers for the Annual Watershed Wide Cleanup
The cleanup is September 20th from 9 AM - Noon. Most St. Olaf students go to Sechler Park here in Northfield. Students do not need to bring anything as we will have trash bags and gloves provided (and a lunch!)
Email Alana Bartolai <alana@crwp.net> if interested in joining or sign up online at http://crwp.net/work/ watershed-cleanup/.
Thursday, July 17, 2014
Resources from the Piper Center
St. Olaf Professional Development Resources:
Grant Eustice (eustic1@stolaf.edu), Fellowships Coach in the Piper Center - Advise students interested in applying for nationally competitive scholarships and fellowships.
Susie Kramer (kramer1@stolaf.edu) Pre-Health Career Coach at the Piper Center. Works with students (freshman-seniors) interested in pursuing a career as a healthcare professional (MD, DO, PT, OT, Nursing, Public Health, Healthcare Administration, Dent, Vet, Pharm, etc.). Feel welcome to schedule a meeting via Ole Career Central for any of your career needs (discerning a path in healthcare, choosing a major, finding a healthcare professional to shadow, internship opportunities, research opportunities, applying to professional schools, resume, cover letter, etc.).
Tuesday, June 3, 2014
ACS Student Rep to the 2014 UN Climate Conference
Become an ACS Student Representative to the UN Climate Conference
Lima, Peru; December 1 – 12, 2014
The deadline to apply to serve as an ACS student representative to the December UN climate conference in Lima, Peru is July 1, 2014. The purpose of this project is to promote climate science literacy among college and university students by employing social media as a tool and the annual UN climate conference as a platform. “Climate Change Literacy and Education” is one of four “Actions” recommended by the ACS Climate Change Public Policy Statement. See the flyer for additional information.
Application procedures and additional information can be found at:
Click on the link: UNFCCC COP 20 Application
Thursday, May 29, 2014
NSF Scholarship to attend Green Chemistry & Engineering Conference
|
Wednesday, May 7, 2014
MPCA Summer Student Worker for Green Chemistry Projects
The Minnesota Pollution Control Agency is seeking a student worker to support green chemistry projects this summer and possibly into the fall depending on scheduling and funding.
The job posting and application procedure is available at https://statejobs.doer. state.mn.us/JobPosting/ 890af31bb1489abbd6578a96dec0bc 0a/View.
You must have a resume on file at the My State Job Search site before you can apply.
Applications will be accepted through May 14, 2014.
Tuesday, May 6, 2014
UMN and ACS to honor legacy of Professor Izaak M. Kolthoff - 12/13 Sep 2014 - Save the Date
Join us as we honor the legacy of legendary chemistry Professor Izaak M. Kolthoff
Public Ceremony
Landmark Designation and Smith Hall Centennial
Friday, Sept. 12, 2014
4 p.m.
Smith Hall, University of Minnesota
207 Pleasant St. SE, Minneapolis
Landmark Designation and Smith Hall Centennial
Friday, Sept. 12, 2014
4 p.m.
Smith Hall, University of Minnesota
207 Pleasant St. SE, Minneapolis
The ceremony includes a plaque unveiling and public dedication in Kolthoff's honor. Speakers will represent the University of Minnesota and the American Chemical Society. The event also includes tours and a reception.
Research Symposium
Honoring Kolthoff's Scientific Legacy
Saturday, Sept. 13, 2014
8:30 a.m.-12:30 p.m.
Smith Hall, University of Minnesota
207 Pleasant St. SE, Minneapolis
Honoring Kolthoff's Scientific Legacy
Saturday, Sept. 13, 2014
8:30 a.m.-12:30 p.m.
Smith Hall, University of Minnesota
207 Pleasant St. SE, Minneapolis
The symposium will feature National Academy of Sciences members:
- Professor Allen Bard, University of Texas at Austin
- Professor Harry Gray, California Institute of Technology
- Professor Laura Kiessling, University of Wisconsin-Madison
- Professor Judith Klinman, University of California, Berkeley
- Professor Richard Zare, Stanford University
Event sponsors include:
- University of Minnesota Department of Chemistry
- University of Minnesota College of Science and Engineering
- Minnesota Section of the American Chemical Society
For more information, visit the event web page or send an email tochemnhld@umn.edu. More information and registration details will be available in June.
Sincerely,
William B. Tolman
Distinguished McKnight University Professor and Chair
Department of Chemistry
Distinguished McKnight University Professor and Chair
Department of Chemistry
College of Science and Engineering
University of Minnesota
University of Minnesota
Subscribe to:
Posts (Atom)